What is treatment resistance?

When clinically meaningful antidepressants entered the market in the mid-twentieth century, they represented a major evolution in the treatment of mood disorders.1, 2 While effective for some, for a significant number of individuals, these treatments are not. In fact, treatment resistance – when an illness does not respond to an adequate course of treatment – affects as many as 60 percent of individuals with conditions like schizophrenia, MDD, bipolar affective disorder, and OCD.3 Read on to learn about Treatment-resistant depression.

Footnotes

1. Howes, O., Thase, M., Pillinger, T. (2021, July 13). Treatment Resistance in Psychiatry: State of the art and new directions. Molecular Psychiatry. https://www.ncbi.nlm.nih.gov/

2. Pereira, V., Hiroaki-Sato, V. (2018, February 1). A brief history of antidepressant drug development: from tricyclics to beyond ketamine. Cambridge University Press. https://www.cambridge.org/

3.Howes, O., Thase, M., Pillinger, T. (2021, July 13). Treatment Resistance in Psychiatry: State of the art and new directions. Molecular Psychiatry. https://www.ncbi.nlm.nih.gov/