What substances are used during psychedelic-assisted therapy and are they effective?

A range of psychedelic treatments are being used by practitioners (psychiatrists, therapists, counselors, guides) in both clinical and non-clinical settings. Some of the most frequently used substances in psychedelic-assisted therapy are ketamine, psilocybin, 3,4-methylenedioxymethamphetamine (MDMA), ibogaine, ayahuasca, mescaline/peyote, lysergic acid diethylamide (LSD) and N,N-dimethyltryptamine (DMT).1

In preliminary studies, these substances have been shown to be effective interventions that target a variety of mental health conditions like depression (including treatment-resistant depression), anxiety, substance dependence, and PTSD. Studies out of Johns Hopkins University and Stanford University have offered seminal findings in this area of research.


1. Robertson, K., (2021 May 25). Psychedelic Therapy is Having a Moment – Here’s What You Need to Know. Healthline. https://www.healthline.com/health/mental-health/psychedelic-therapy